This is not necessarily a major issue. It is simply an advisory that a significant number of rows in the table have been inserted, updated or deleted and that in order to have reliable statistics, a vacuum analyze should be done.
Depending on the number of rows in the table and the difference between actual row count and and the current statistics row count, you can decide if you need to vacuum analyze or delay.
One rule of thumb is to consider the response time of queries against that tablet. IOW, are DML queries involving that table completing within a couple of seconds? If yes, you can delay a while or wait for autovacuum to be done on that table. If the DML is taking more than a few seconds, then yes, it is advisable to vacuum analyze it.